081130 SUNDAY “Helen”
Julie, Paula, Katy and Jasmine do Fran. . . (and it’s alright Katy, Fran makes most of the veterans cry too).
3 rounds for time.
21 kettlebell swings 1.5 pood or 54lbs
12 pull ups
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Researchers identify a potentially ‘universal’ mechanism of aging
Oberdoerffer found that a primary function of sirtuin in the mammalian system was to oversee patterns of gene expression (which genes are switch on and which are switch off). While all genes are present in all cells, only a select few need to be active at any given time. If the wrong genes are switched on, this can harm the cell. (In a kidney cell, for example, all liver genes are present, but switched off. If these genes were to become active, that could damage the kidney.) As a protective measure, sirtuins guard genes that should be off and ensure that they remain silent. To do this, they help preserve the molecular packagingâ€”called chromatinâ€”that shrink-wraps these genes tight and keeps them idle. . .
. . .”We then began wondering what would happen if we put more of the sirtuin back into the mice,” says Oberdoerffer. “Our hypothesis was that with more sirtuins, DNA repair would be more efficient, and the mouse would maintain a youthful pattern gene expression into old age.”
That’s precisely what happened. Using a mouse genetically altered to model lymphoma, Oberdoerffer administered extra copies of the sirtuin gene, or fed them the sirtuin activator resveratrol, which in turn extended their mean lifespan by 24 to 46 percent. . .
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